Not really. I have a sort of taoist take on the world and I pray sometimes (no idea to what I'm praying!). I think the existence of a higher power is unlikely, but I have no way of knowing, but prayer helps me anyway (like a lot) so it almost doesn't matter either way to me.
This is going to sound like the biggest hippie stoner thing, but sometimes things are real without necessarily being literally real, like they have an emotional or psychological reality to them. That's where I'm at with spirituality. I also really like what Carl Sagan had to say about having a sort of reverential awe of the universe.